Mechanism Explorer
From genes to drugs that exist today.
Name a disease or list its genes. We find every drug already known to act on those genes, rank approved drugs first, flag withdrawn ones, show the pathways the genes share and how much human genetic evidence backs each gene.
Results appear here.
Repurposing candidates
| # | Drug | Status | Acts on | Action | Evidence |
|---|---|---|---|---|---|
| Run a search to see candidates. | |||||
Shared pathways
| Pathway (Reactome) | Genes in it | FDR |
|---|---|---|
| Pathways the genes share appear here. | ||
Genetic evidence
ClinVar variants classified pathogenic or likely pathogenic, per gene. More pathogenic variants means stronger human evidence that the gene matters in disease.
| Gene | Pathogenic / likely pathogenic | All variants | Example conditions |
|---|---|---|---|
| Gene evidence appears here. | |||
Hypotheses, not treatments
A drug that acts on a disease gene may not help, may push the gene the wrong way, or may not reach the right tissue. Use these leads to decide what to read and test next, and talk to a clinician before any health decision. Sources: DGIdb, Reactome, STRING, ClinVar and UniProt, queried live.