Free for everyone · ask the Master Disease Agent below

Every disease's evidence.
Read together.

One question searches the literature, the trial registry, the compound database and the protein atlas at once, then AI ranks what could work, with every claim linked to its source.

✓ Free for everyone. No sign-up, no paywall. Ask about a disease, a symptom, a drug or a trial.

Meet Cura, the agent's pet.

Cura listens while you type, reads the literature while the agent searches, charts the odds, celebrates when an answer passes review, and can read every answer aloud. Leave it alone for a while and it dozes off. Tap it to say hi.

Second brain: not connected

Try one of these:

Research information, not medical advice. In an emergency, call your local emergency number.

Connect your Obsidian second brain

The agent reads the notes that match each question, so its answers build on what you already know, and you can save any answer back into your vault. Your notes are read in this browser, only the few excerpts that match a question go with it, and nothing from your vault is stored on our servers or in the agent's memory.

Live vault best

  1. In Obsidian, open Settings → Community plugins, then install and enable Local REST API.
  2. Copy the API key from the plugin's settings and paste it below.
  3. Open https://127.0.0.1:27124 once in this browser and accept the certificate, so the page can reach Obsidian.

Obsidian has to be open on this computer while you chat. The key is kept only in this browser.

Or import notes, no plugin needed

Pick your vault folder. The notes stay in this tab and are gone when you close it.

Saving answers

With a live vault, answers are written straight into that folder. Otherwise "Save to Obsidian" opens Obsidian with the answer as a new note.

Runs live against the public biomedical record

PubMedClinicalTrials.govChEMBLUniProtHuman Disease OntologyOpenAI
Simulations

Watch the biology behind the evidence.

Short animated simulations of what the research is actually about: how diseases work, how drugs act on them, and how our agent reads the evidence. Pick one to play it.

Find Your Cure: herpes simplex · All simulations

How CRISPR edits a gene

Find, cut, repair: the gene-editing step behind a new generation of approved therapies.

How an mRNA vaccine works

From a recipe in a nanoparticle to antibodies ready for the real virus.
Find Your Cure

Name a disease. See what could treat it.

Our Master Disease Agent searches every connected database, ranks treatments by evidence, checks for withdrawn or failed drugs, and shows the historical odds that each one reaches approval.

1

Search everything at once

Literature, trials, compounds and protein targets are queried in parallel, live, the moment you ask.

2

Rank and check

AI ranks the candidates by evidence. Then a rules-based check flags anything withdrawn or stopped, whatever the AI said.

3

See the odds

Each candidate shows how often drugs at its stage have historically gone on to be approved, so you know how far it has to go.

The platform

Built for the questions that decide what to research next.

Live retrieval

Four databases, one query.

Each source has its own timeout. If one is slow or down, the others still report, and the brief says exactly which one failed. Nothing is cached sample data.

4 sources
Safety check

No withdrawn drug at the top.

ChEMBL withdrawal records and stopped trials push a candidate down and explain why.

Approval odds

Know how far a drug has to go.

Phase-by-phase historical rates from industry-wide clinical development data.

Memory

It learns from use.

Past runs and researcher ratings are recalled for related diseases, as hints only.

API

Build on it.

Every capability is a documented REST endpoint. API reference

4
public databases queried live for every brief
14
connectors health-checked in public on our status page
<60s
typical time for a full AI brief
0
sample or made-up results: if a source fails, we say so
Who it's for

For people who decide what to research next.

Patients and families can use Find Your Cure to understand the research landscape and bring better questions to their doctor. Researchers get the state of a field in a minute instead of a week.

Translational researchers

See the state of a disease area before committing a lab's time to it.

Drug repurposing teams

Find approved and clinical-stage compounds that already touch a disease's targets.

Patients and advocates

Understand which treatments are approved, which are in trials, and which have failed.

Hypotheses, not prescriptions.

CITADEL is a research tool. Its output is a starting point for expert review, built from public data that can be incomplete or out of date. It is not medical advice. Always talk to a qualified clinician about treatment, and check any finding against its source records. Read our limitations.

Start with a disease. End with evidence.

Simulation

See the science move.

All simulations →